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Diabetes lowers exposure by about 15% and blunts the downstream response. Lean, metabolically healthy users sit outside every efficacy trial

The classification and cross validation were performed using the wrapper function offered by the caret package in MetaboAnalyst software (Xia and Wishart 2011)

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Pickart, L., Thaler, M

This is distinct from stimulants or acetylcholinesterase inhibitors, which modulate neurotransmitter availability rather than synaptic architecture

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