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8) Abnormal Red Blood Cell Destruction Hemoglobin is lower in conditions that cause abnormal red blood cell destruction (hemolytic anemia), including [56, 57, 58, 59]: infections such as malaria Enlarged spleen hereditary conditions such as sickle-cell anemia autoimmune anemia (antibodies that attack red blood cells) 9) Genetic Disorders in Hemoglobin Production There are several genetic disorders in which hemoglobin is abnormal, resulting in deformed red blood cells, such as [57, 60]: Sickle-cell anemia Alpha and beta thalassemia Sickle-Cell Anemia Sickle-cell anemia is caused by a mutation in the gene for one of the hemoglobin chains

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