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10.3390/ijms241310978 42 SilzerT

GPX4 is the only enzyme known to reduce complex phospholipid hydroperoxides directly (Xia et al., 2021)

The expression of both circFNDC3B and SLC7A11 is enhanced in clinical OSCC tissues, whereas the expression of miR-520d-5p is reduced, and the silencing of circFNDC3B inhibits tumor growth in vivo (Yang et al., 2021)

Both mitochondrially targeted ZFNs and TALENs are composed of two functional units: a component that recognises a specific DNA sequence and a component that mediates DNA cutting

These findings underscore the therapeutic potential of targeting mitochondrial metabolism in the OXPHOS-driven mitochondrial subtype GBMs, a strategy that may differ from interventions aimed at glycolytic-dominant subtypes of GBM

By blocking this pathway, GPS can reduce the expression of fibrotic genes and collagen production, thereby mitigating liver fibrosis