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Controls Angiogenesis: vascular density +200% (IGF-1-mediated) Collagen deposition: increased matrix synthesis Re-epithelialization: keratinocyte migration +150% 3

Existing evidence also indicates that acupuncture can modulate the expression of peroxisome proliferator-activated receptor- (PPAR) proteins and genes

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Moreover, another study documented that 400 mg/d riboflavin supplementation during 3 months had the same favorable effects as 500 mg/day sodium valproate on patients with migraine (36)