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ACC 57) at passage 4-25 were cultured in Dulbeccos Modified Eagle Medium (DMEM) (Gibco, Ref: 41966029, Thermofisher Scientific,Waltham, Massachusetts, United States) supplemented with 10% fetal bovine serum (FBS) (Gibco, Ref: 10270106, Thermofisher Scientific,Waltham, Massachusetts, United States) in humidified air at 37C and 5% CO 2

Although iron overload is a major characteristic of ferroptosis, its potential regulatory mechanisms are still unknown

340 Furthermore, the increased production of inflammatory mediators like TNF- and the activation of stress kinases such as JNK, PKR, and IKK could promote the inhibitory serine phosphorylation of IRS-1, downregulate insulin signaling in the brain, and induce AD neurological dysfunction

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, lisdexamfetamine) and amphetamine concentrations predicted by the one-compartment pharmacokinetic model (black lines)

The results revealed that the compound exhibited favorable sustained-release characteristics in PBS buffer (pH 7.4) at 37 C (Figure 3A, the 3b series compounds demonstrated higher cumulative H 2 S release