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FEMS Microbiol Rev 29 , 10411050, (2005)

These studies often used doses ranging from 250mg to 500mg per day

Inhibiting LPCAT3 can make cancer cells less sensitive to ferroptosis, and experimenters exposed kidney cancer cell lines treated with LPCAT3 inhibitors to certain concentrations of ferroptosis inducers and found that the treated cells were insensitive to ferroptosis, while the levels of arachidonic acid phospholipids decreased significantly, indicating that inhibiting LPCAT3 decreased the synthesis of specific lipids that trigger ferroptosis, and the cells were much less likely to undergo ferroptosis, confirming the important role of LPCAT3 in ferroptosis (28)

Cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), are lack of effective therapy and with huge unmet medical needs

Researchers investigate its role as a cofactor for glutathione peroxidase and S-transferase enzymes, and examine its involvement in xenobiotic metabolism and heavy metal chelation pathways in cell cultures

doi: 10.1016/j.molcel.2017.12.021 37 ReniereM