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Kossoff EH, McGrogan JR, Bluml RM, Pillas DJ, Rubenstein JE, Vining EP

The anti-inflammatory mechanisms of ALA and L-carnitine are also particularly noteworthy

However, when in excess, as is the case in PD-neurons, NO alters axo-dendritic function impairing synaptic signaling, vesicular trafficking, and dopamine homeostasis (Fig

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Administration of the resveratrol-rich supplement (resveratrol: 8 mg/day for 6 months, then 16 mg/day for another 6 months) significantly improved the profile of circulating inflammatory markers, reducing levels of C-reactive protein (CRP) and Tumor Necrosis Factor- (TNF-), as well as the level of thrombogenic factor, Plasminogen Activator Inhibitor-1 (PAI-1) (109)