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Beghi E, Pupillo E, Bonito V, Buzzi P, Caponnetto C, Chi A, Corbo M, Giannini F, Inghilleri M, Bella VL, Logroscino G, Lorusso L, Lunetta C, Mazzini L, Messina P, Mora G, Perini M, Quadrelli ML, Silani V, Simone IL, Tremolizzo L

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A meta-analysis of 15 studies and 15,498 subjects found an increased relative risk of HTN with higher circulating TMAO levels (1.14, 95% CI 1.081.20), and although the RR is relatively small for such a large sample size, this relationship was dose-dependent with a 1.014% increase in HTN risk for every increase of TMAO level by 1 mol/L [70]

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Altogether, the carnitine carboxylate is fully engaged with stabilising interactions, which is consistent with the high-affinity nature of transport 3