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For the chromatographic metabolite separation, the Vanquish UPLC systems were coupled to a Q Exactive HF (QE-HF) mass spectrometer equipped with HESI (Thermo Fisher Scientific, Waltham, MA)

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Pb 2+ can replace not only Ca 2+ from their natural binding sites, but also structurally similar Zn 2+ , Fe 2+ , or eventually Cu 2+ ions

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