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Similarly, in periodontal tissues, it induces ferroptosis in fibroblasts by activating the HIF-1/p38 Mitogen-Activated Protein Kinase pathway and enhancing HIF-1/Cyclin-Dependent Kinase 9/ Bromodomain-Containing Protein 4 interactions, leading to NCOA4-mediated ferritinophagy (Zhao et al., 2020)

KYNA acts as an NMDA receptor antagonist or through the inhibition of the 7 nicotinic acetylcholine (7nACh) receptors whereas QA acts as an agonist toward the NMDA receptors, thus promoting excitotoxic neuronal damage [220]

It results in oxidative stress due to excessive reactive oxygen species (ROS) generation, which contributes to cell damage and death

Hutkins, R

Further studies have demonstrated that UPF overconsumption is associated with increased eating rates and higher energy intake (125, 126)

The Immediate Effect of COVID-19 vaccination on Anticoagulation Control in patients using vitamin K antagonists