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Inside the endosome and due to the low pH and ferrireductases (such as six transmembrane epithelial antigen of the prostate 1 [STEAP-1]), Fe 3+ dissociates from the complex and becomes Fe 2+ , which leaves the endosome through the transporter divalent metal transporter 1 (DMT1) ( Figure 1 )

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Some human studies involving related pineal peptides, especially epithalamin, reported lower mortality and favorable aging-related outcomes in older populations, but there is no modern large-scale proof that Epitalon itself extends human lifespan