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These compounds, in the course of their auto-oxidation, produce free radicals, which in turn oxidize GSH and thereby activate the chain reaction of events previously outlined

The trafficking itinerary that moves GLUT4 to and from the cell surface is complex, involving a series of overlapping processes that (1) render GLUT4 insulin responsive by sorting it into GSVs, and (2) promote GLUT4 accumulation at the PM in adipocytes or sarcolemma and t-tubules in muscle in response to insulin signalling (Figure 3)

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21 Moreover, extracellular lactate-induced H3K18la in T helper 17 (Th17) cells, a subset of CD4 + T helper cells secreting IL-17, contributes to transforming pro-inflammatory T cells into Treg cells