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Such as, PtMo-Au, Pt/PCN-224(Fe)/PEG, Pt/BTO@MCMPs, Ti 3 C 2 -Pt, Zn/Pt SATs, Pt/CeO 2X S X , BiF 3 @BiOl@Pt-PVP, TiO 2 @Pt/GOx, MoN-Pt@PEG, CaCO 3 @Pt-TiO 2 , Pt-ZnO, CF@Pt, and Pt-B-P NPs [227,228,229,230,231,232,233,234,235,236,237,238,239]

Key limitations of the existing evidence include: Small sample sizes in many studies Heterogeneous patient populations Variable dosing regimens (typically 35 grams daily) Short follow-up periods (often 4-12 weeks) Inconsistent outcome measures Potential publication bias favouring positive results Some studies have investigated combination approaches