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[8] But could joint pain be affected by B12 deficiency

You are/aren't

May improve heart health Some studies show that certain people could improve their heart health if they take B vitamins, but its not recommended for everyone

A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data