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subsequent sections focus on PD-relevant models (MPTP, 6-OHDA)

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Next, glutaminases (GLSs), including glutaminase 1 (GLS1), glutaminase 2 (GLS2) and GAC (a splicing isoform of GLS1), convert Gln to glutamate (Glu) in the mitochondria, releasing ammonium ions ( Figure 1 ) (14)

In mammals, GSH conjugates are often further metabolized by hydrolysis and N-acetylation, either in the gut or in the kidney, to give N-acetylcysteinyl conjugates known as mercapturic acids, which are excreted in the urine

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