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Description

Aggregated and deposited -synuclein is directly associated with the disruption of cellular homeostasis and neuronal death (Jenner 2003)

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

Silencing SIRT1 gene or inhibiting it pharmacologically with Ex-527 can reduce cell ferroptosis and inhibit EMT, 90 suggesting that epigenetic reprogramming of EMT helps to promote ferroptosis in HNC cells