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10.1016/j.fct.2015.03.020 73 OoiJ

1 High levels of vitamin B2 potentially increase the activity of MTHFR, which may lead folate to provide a greater amount of methyl groups for the methionine synthesis enzyme

Here is a graphical representation of what is going on in a mitochondrion in depression

doi: 10.3390/antiox11010133

Yet, a large number of clinical trials have failed to show beneficial effects of antioxidants for these pathologies, and a handful of trials have suggested that antioxidants increase mortality