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It is worth noting that many of the top ATF4-dependent genes that scored as being induced by the ISR alone showed some degree of rapamycin-sensitive induction with insulin but did not reach statistical significance in the RNA-seq analyses

In various diseases, multiple sites are modified simultaneously [123]

341,342 Although direct evidence for LPA-PPAR and LPA-RAGE activation is lacking, the established roles of these receptors in dendritic cell migration and Th2 responses suggest the possible augmentation of these responses by LPA