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Description

Zheng J, Zhou Z, Qiu Y, Wang M, Yu H, Wu Z

The resulting ordered multivalent network enables simultaneous engagement of multiple POI and E3 ligase copies, promoting sustained, dose-dependent degradation and improved tumor retention

In this context, Hcy serves as a substrate for methionyl-tRNA synthetase (MARS), which catalyzes its conversion into homocysteine thiolactone (HTL), a highly reactive metabolite with enhanced cytotoxicity[14]