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After activation, NF-B rapidly translocates to the nucleus and binds specifically to target genes, thereby initiating the transcription of Endothelin-1 (ET-1) and inflammatory cytokines, such as tumor necrosis factor (TNF), Interleukin-1 (IL-1), and Interleukin-6 (IL-6)[17]

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Gow AJ, Duran D, Malcolm S, Ischiropoulos H

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Advances in genomic, transcriptomic, proteomic, and metabolomic approaches to study biotic stress in fruit crops

It should be noted that the mechanism relies on a sufficient H + buffer capacity of the sieve tubes and comes with a progressive alleviation of the K + gradient to maintain charge balance