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In contrast, plain sterile water is preservative-free and belongs to a single-entry class

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lactate, L-glutamate, and pyruvate, as their major carbon sources, and that the relative abundance of these carbon sources is different in the different host microenvironments relevant for meningococcal infection (nasopharynx, blood, cerebrospinal fluid, epithelial cells, endothelial cells, phagocytes) and subject to variation during meningococcal invasive disease

i.e., highly dynamic sets of many rapidly interconverting, structurally distinct conformations, and this structural fuzziness (inherent structural heterogeneity), is often not a limitation but a fundamental aspect of their functions

2022;15:eabj4009