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Underlying health conditions: Some health conditions, such as gastrointestinal disorders or liver disease, can affect B12 absorption and metabolism, potentially leading to shorter-lasting benefits from B12 injections

Through laboratoryexperimentationon various animals, including rodents, pigs, dogs, and humans, the unique mechanism of AOD-9604 has been identified, which primarily stimulates the release of fat from adipose tissue, inhibits the accumulation of new fat in adipocytes, and promotes fat oxidation

NNMT activity is elevated in adipose tissue and linked to reduced NAD+ availability, impaired mitochondrial function, and metabolic inflexibility

Deficiency of carnitine can limit fat oxidation efficiency

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