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In a robust, healthy system, the liver, kidneys, and gastrointestinal tract work in concert to identify, bind, and excrete these toxic elements before they can accumulate in vital organs

Moreover, the BRCA1 loss mutation, like oncogene activation (RAS, NF-B, TGF-), in cancer cells will drive the initiation of metabolic symbiosis phenotype between tumor cells and fibroblasts in both primary and metastatic cancers (226)

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The 2024 NICE guideline NG239 sets out a more intensive loading schedule for patients with neurological involvement precisely because their starting point is worse

6 Cell lines do not form LB-like inclusions but show signs of lysosomal dysfunction

Qu et al., 2024)