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(2016) found a significant reduction in the difference between button presses for rewarded and unrewarded stimuli following 50 mg naltrexone (n = 40) compared with placebo (n = 40), indicating reduced motivation to exert effort for rewards after opioid blockade

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The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier

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The VEGFA and IL8 protein expression levels were semi-quantitatively evaluated using the H -score system

Firstly, we found that plasmalogen PCs were depleted in LID compared to non-LID animals in the GPi, Cl and PrG, whereas they were increased in non-LID compared to MPTP animals