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PARP-Mediated DNA Repair: Poly-ADP-ribose polymerases (PARPs), particularly PARP1, consume NAD+ as a substrate to detect and signal DNA damage and initiate repair

Detection and management of amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with anti-amyloid beta therapy

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However, with prolonged persistence, it leads to chronic progressive ventricular dysfunction and eventual mortality (Pereira et al., 2017