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The injection can be a standalone treatment, but its more commonly incorporated into other treatments, such as physical therapy

The NICE Clinical Knowledge Summary on B12 and folate deficiency recommends assessing the underlying cause before choosing a treatment path, which is why speaking to a pharmacist or GP first matters

Obesity-induced suppression of sirtuin activity contributes to oxidative stress, impaired mitochondrial integrity, and potentially transgenerational metabolic dysfunction [54]

Dosing should be determined by the prescribing physician based on the severity of joint involvement, body weight, and other individual factors

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