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Patients should be monitored by their prescribing clinician, especially those taking cardiac medications

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'Hugely expensive' Irene Roberts, professor of paediatric haematology, at the University of Oxford, said: "Reducing or stopping transfusions is important for patients with thalassaemia because they are a double-edged sword- essential for survival but also responsible for life-changing, life-shortening side-effects

The B12 is then combined with a different protein, which is made in the stomach, before it can be absorbed

Patients often detect a visible protrusion, sensation of pressure, or mild discomfort