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Biochemistry 51, 68046815

Gut Microbiota in Human Metabolic Health and Disease

IRE1 facilitates serine palmitoyltransferase gene transcription via XBP1s, leading to the release of extracellular vesicles (EVs) from hepatocytes, thereby recruiting macrophages to foster hepatic inflammation and injury in NASH mice [41]

These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body

Chang, C.-H., et al

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