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Supplementary material The Supplementary Material for this article can be found online at: References 1 AbaleaV.CillardJ.DubosM.SergentO.CillardP.MorelI

The AhR, a crucial sensor of environmental signals, participates in the DNA damage process through multiple mechanisms upon activation: By directly upregulating the expression of metabolizing enzymes such as cytochrome P450s (CYP1A1, CYP1B1) and aldo-keto reductases (AKRs), AhR promotes the metabolic activation of procarcinogens like polycyclic aromatic hydrocarbons (PAHs) (Shen et al., 2005