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A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression

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While transcriptomic studies have highlighted shifts in lysosomal activity, redox balance, and lipid metabolism with increased passage number 17 , comprehensive mechanistic analyses linking these genetic changes to metabolic flux alterations remain lacking

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Prieto L, Quesada JF, Cambero O, Pacheco A, Pellicer A, Codoceo R, et al

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest