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Institutional Review Board Checklist Tick off the following points to facilitate the review process of your proposal by the Institutional Review Board (IRB): Faculty advisor has gone through entire proposal and gives the go ahead to proceed to IRB (in case of students)

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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by Pyruvate Dehydrogenase and that TCA cycle flux is diminished (Gray et al., 2015, Rauckhorst et al., 2017)

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