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While the results are yet to be published, it has been reported that the drug failed to meet the primary endpoint of the trial (Carroll, The failure of these clinicals trials might suggest that the effects of anti-inflammatory treatments (e.g., nonsteroidal anti-inflammatory drugs) and global immunosuppression (e.g., corticosteroids) are probably too broad, current approaches do not consider the high heterogeneity in microglia and astrocyte phenotypes (Ransohoff, 2016b