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For instance, continuous increases in myelin debris cannot be accommodated by microglia in the long-term, which subsequently leads to dysfunctional lysosomal activity and a noticeable increase in insoluble lipofuscin-like granulesa marker of aging, dystrophy and possibly senescencein mice (Safaiyan et al., 2016)

In lung cancer, the TME favors M2 polarization, characterized by enhanced OXPHOS, FAO, and upregulation of ARG1 and IL-10

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Smith Y, Charara A, Paquet M, Kieval JZ, Pare JF, Hanson JE et al (2001)

Implement 24-month safety surveillance programs quantifying long-term adverse event incidence

Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis