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This occurs because creatine increases the amount of phosphocreatine stored in your muscles, leading to more water being pulled (1) into those muscle cells

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Furthermore, SHLP3 had no significant effect on the basal levels of p-AKT-S473 and p-AMPK-172 compared to control samples

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It exerts a critical physiological effect in the excretion of UA in the kidney and intestine (Maliepaard et al., 2001