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45 A placebo-controlled trial that included 60 participants with age-related hearing loss found 30 days of treatment with 160 mg of water-soluble CoQ10 daily resulted in hearing gains at mid-range and higher frequencies compared with 50 mg per day of vitamin E or placebo

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Exposure to the drug induced a mitochondria-independent mode of cell death due to the induction of reactive oxygen species (ROS) through erastin-mediated activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase

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