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Phosphorylation and positive regulation of the phosphorylation process are usually involved in cell growth, apoptosis and signaling pathways through post-translational modification and cellular metabolism, and abnormal alteration in phosphorylation contribute to diseases, including cancers 29

Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids

Metformin affects b12 absorption through multiple pathways including interference with calcium-dependent membrane binding in the ileum

KPV, also known as Lysine-proline-valine, is a naturally occurring tripeptide [that] has been shown to attenuate the inflammatory responses of colonic cells[and] exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways (Xiao et al., 2017)