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358 Abnormal expression of transport proteins/receptors in the BBB, such as downregulation of LRP1 which exports A from the brain to the blood, impaired function of Pgp, and upregulation of RAGE that facilitates the entry of A from the blood into the brain, could be potential reasons for impaired A clearance and substantial accumulation in the brain

3.15 Construction of the prognostic model We used the TCGA lung adenocarcinoma dataset (n = 497) as the training set, and the GEO datasets GSE31210 (n = 226) and GSE13213 (n = 117) as independent validation cohorts

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(May 2009)