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Additional glutamine residues can confer toxicity through various mechanisms, including irregular protein folding and degradation pathways, altered subcellular localization, and aberrant interactions with other cellular proteins [141]

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doi: 10.1038/s41598-018-21243-x 3 CoghillDBonnarSSethSDukeSGrahamJ

In mammalian alpha, pi and mu GSTs a tyrosine residue performs this function, whereas in all the plant enzymes this residue is replaced with a serine

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