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Neurology 68(5):384386 Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Loss of these dopamine-producing nerve cells results in motor impairment, as well as non-motor symptoms such as depression, sleep disturbances, and cognitive impairment

Purinergic P2X3 signaling has emerged as a promising therapeutic target for the treatment of BIPN (Holzer et al., 2022)

In general, older red blood cells are more susceptible to destruction than young ones

The Human Evidence Gap: Three Studies, Fewer Than 30 Subjects Despite three decades of animal research, the total published human evidence for BPC-157 as of early 2026 consists of three studies involving fewer than 30 subjects combined