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The peptide enhances expression of key transcription factors including Lhx2 and Sox9 essential for hair follicle stem cell maintenance and activation while modulating Wnt/-catenin signalinga critical pathway for hair follicle morphogenesis and cyclingwith treated follicles showing enhanced -catenin nuclear localization and increased Wnt target gene expression

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Although both semaglutide and cagrilintide induce satiety, they exert their effects in different regions of the brain, suggesting a synergistic effect on appetite regulation, warranting the investigation of these drugs as a combination therapy