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Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

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Results ADH5 limits FA cytotoxicity even in the presence of DNA repair It is still unresolved how FA compromises cellular function, especially in cells proficient for DNA repair, such as those from patients harbouring mutations in the genes coding for FA-metabolizing enzymes

7.1.4.1 BEZ235 BEZ235 in RCC cell lines has shown more effective cell growth arrest and anti-tumor activity in vitro and in vivo than mTORC1 inhibition alone (248)