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Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

Recent evidence has shown that TLRs are expressed in diverse tumor cell populations (including tumor stem cells) together with cancer-associated fibroblasts, tumor-associated macrophages, myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and adipocytes in the TME, participating in both promotion and inhibition in tumor growth (243)