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group II (LPS group), this group was only assigned to establish the acute orchitis model by injecting 0.5 mL saline containing LPS (Sigma-Aldrich, MO, United States) at a dosage of 5 mg/kg intraperitoneally ( After 24 h of the last treatment, the rats were weighed, and blood samples were collected from the retroorbital venous plexus under anesthesia (ketamine, 50 mg/kg, and xylazine, 2.20 mg/kg) ( 2.4 Semen examination Semen collection was performed by longitudinally opening the cauda epididymis, and sperm motility was examined microscopically

Glia 22:1118 Krejsa CM, Franklin CC, White CC, Ledbetter JA, Schieven GL, Kavanagh TJ (2010) Rapid activation of glutamate cysteine ligase following oxidative stress

In accordance to that, PERK inhibitor GSK2656157 rescued SSI-4-mediated cytotoxicity, while IRE1 inhibitor 48c demonstrated only milder cytoprotective effects at higher doses and ATF6 inhibitor Ceapin A7 had no effects (Supplementary Fig

Emerging mechanisms and disease relevance of ferroptosis

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