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Description

NIK phosphorylates and activates the NF-B kinase subunits of alpha (IKK alpha) inhibitors, and the liver NIK/IKK alpha cascade inhibits liver regeneration

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These cytokines also increase the production of matrix metalloproteinases (MMPs) and receptor activator of nuclear factor kappa-B ligand (RANKL), which leads to osteoclastogenesis and osteoclast activation, which deteriorates bone and cartilage in joints (44, 45)