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After initially discovering that group I metabotropic glutamate receptor signaling-dependent LTD is impaired in the hippocampus of FMR1 (Fragile X Mental Retardation gene 1) knock-out mice (Huber et al., 2002) and that the gene product of FMR1, FMRP (Fragile X Mental Retardation Protein), is a potent transcriptional repressor (Aschrafi et al., 2005

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Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice

106 However, because of its antioxidant properties, NAC might be a potential add-on therapy in COPD patients

Hence, TP53 is classified as a tumor suppressor gene

Published human clinical trials for KPV in IBD or arthritis are lacking