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For decades, most metabolic and endocrine trials enrolled predominantly male subjects, leaving women to extrapolate from biology that was never designed to map onto theirs

The research literature reports a favourable safety profile with few side effects at therapeutic doses

Inadequate absorption or utilisation of Vitamin B12 because of age, gastric abnormalities such as Coeliac disease, inflammation of the stomach or intestines, after stomach and bowel surgery, and inflammatory bowel diseases (Crohns disease)

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While the pill is more costly, studies show that both the oral and injectable forms are effective

The behavioral response of the rats to the injection of a 5% formalin solution into the hind paw was used to assess pain and analgesia [9]