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While this study provides valuable in vivo evidence for the antitumor activity of Leucocalocybe mongolica polysaccharide (LMP), several limitations should be noted which are common to early-stage pharmacological natural product research

Research has found that pueratin reduces FSH and LH levels in a dose-dependent manner, stimulates E2 secretion, upregulates Bcl-2 protein expression, downregulates Bax protein expression, inhibits apoptosis, and protects ovarian reserve function [87]

Yet, measures of specific neuropathic impairments (secondary outcomes) improved with lipoic acid supplementation (78)