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doi:10.1016/j.amjoto.2021.103337

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Some protocols recommend splitting this dose into morning and evening administration for sustained effect

Other than patients who have had their stomachs bypassed, there is also an autoimmune condition known as pernicious anemia that leads to a deficiency of intrinsic factor, lack of ability to absorb vitamin B12 and therefore poor availability of cobalamin (vitamin B12)