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Journal of Physiology-Paris 87:313327 Sikiric P, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, Drmic D, Stupnisek M, Misic M, Vuletic LB, Pavlov KH (2018) Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157

Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro

In normal human fibroblasts, GHK reduces the secretion of TGF- and inflammatory cytokines, such as TNF- and IL-6, to relieve skin inflammation and prevent the formation of hypertrophic scars (Gruchlik et al., 2012) [8] The treatment of rats, mice, and pigs with GHK effectively activate systemic healing throughout the animal

Low zinc levels heighten endothelial cell vulnerability to LPS-induced apoptosis, whereas higher intracellular zinc supports defenses against apoptosis, possibly via nitric oxide pathways [473]