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All other tested strains remained unaffected (Extended Data Fig

45 Nonetheless, RIG-I, not MDA5, appears to interact with the Mtb-specific mRNAs polA and ppe11 (ref

Theyre also anti-inflammatory, supporting skin hydration and overall skin integrity

[1] Deamidation proceeds much more quickly if the susceptible amino acid is followed by a small, flexible residue such as glycine whose low steric hindrance leaves the peptide group open for attack

2016;365:89-95 Wennberg AMV

The (1.55 CSF) term is included because CSF contains more water than GM or WM, and thus CSF tends to lower water-scaled estimates of the metabolites, in addition to the usual partial volume effects 11